Article
Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.
Biochemical and biophysical research communications - 21 Apr 2006
Arsov Todor, Larter Claire Z, Nolan Christopher J, Petrovsky Nikolai, Goodnow Christopher C, Teoh Narcissus C, Yeh Matthew M, Farrell Geoffrey C
Abstract excerpt
The biochemical differences between simple steatosis, a benign liver disease, and non-alcoholic steatohepatitis, which leads to cirrhosis, are unclear. Fat aussie is an obese mouse strain with a truncating mutation (foz) in the Alms1 gene. Chow-fed female foz/foz mice develop obesity, diabetes, and simple steatosis. We fed foz/foz and wildtype mice a high-fat diet. Foz/foz mice developed serum ALT elevation and...
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