Article

Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis

2025-06-11

Abstract excerpt

<h4>SUMMARY</h4> Cholesterol overload drives metabolic dysfunction-associated steatohepatitis (MASH). While the liver maintains homeostasis by exporting cholesterol via very low-density lipoprotein (VLDL) secretion, this process is paradoxically suppressed under cholesterol excess by insulin-induced gene 1 (INSIG1), which inhibits sterol regulatory element-binding protein 1 (SREBP1) activity. How VLDL secretion p...

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Literature Corpus work: 3ffb2469-5b51-5aad-9351-5bcbd9580fba
DOI: 10.1101/2025.06.09.657856

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