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Maternal palmitic acid overload establishes a SETD1A-dependent epigenetic memory that programs offspring susceptibility to metabolic liver disease

2026-03-06

Abstract excerpt

<title>Abstract</title> <p>Metabolic dysfunction-associated fatty liver disease (MASLD) has emerged as a major global health concern, with prevalence rising alarmingly in the pediatric population. Maternal nutrition and maternal body mass index (BMI) influence the propensity of the offspring to develop MASLD during childhood and adulthood, but the mechanisms underlying this maternal inheritance are unknown. Here,...

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Literature Corpus work
87545ecb-fb81-5651-bf95-38fc9faf82cf
DOI
10.21203/rs.3.rs-8949727/v1
Open publication

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Maternal palmitic acid overload establishes a SETD1A-dependent epigenetic memory that programs offspring susceptibility to metabolic liver diseaseDOI 10.21203/rs.3.rs-8949727/v1
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