Article

RNA isoform diversity, splicing variants, and switching in single cells of the Alzheimer’s disease brain

2025-09-29

Abstract excerpt

<title>Abstract</title> <p> Alzheimer’s disease (AD) is the most common cause of dementia, yet its molecular causes remain incompletely understood. RNA diversity in part arising from dysregulated splicing may contribute to AD pathogenesis; however, the ability to interrogate the resulting full-length isoforms in single brain cells has been technologically limited. Here we report the use of PacBio Kinnex long-rea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd43c7e1-6782-5614-b50f-9bc94d8ce734
DOI: 10.21203/rs.3.rs-7436496/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA isoform diversity, splicing variants, and switching in single cells of the Alzheimer’s disease brainDOI 10.21203/rs.3.rs-7436496/v1Read

Using deep long-read RNAseq in Alzheimer’s disease brain to assess medical relevance of RNA isoform diversitySemantic proximity Read

scREAD: A single-cell RNA-Seq database for Alzheimer’s DiseaseSemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

A Single-cell and Spatial RNA-seq Database for Alzheimer’s Disease (ssREAD)Semantic proximity Read

Cell-Type-Resolved Isoform Atlas of Human Tissues Reveals Age and Alzheimer’s Disease-Associated Splicing ChangesSemantic proximity Read

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brainSemantic proximity Read

Avoiding false discoveries: Revisiting an Alzheimer’s disease snRNA-Seq datasetSemantic proximity Read

Single-cell transcriptomic analysis elucidates APOE genotype specific changes across cell types in two brain regions in Alzheimer’s diseaseSemantic proximity Read

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanismsSemantic proximity Read

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read

Surveying the landscape of RNA isoform diversity and expression across 9 GTEx tissues using long-read sequencing dataSemantic proximity Read

Single-cell RNA sequencing analysis of human Alzheimer’s disease brain samples reveals neuronal and glial specific cells differential expressionSemantic proximity Read