SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity

Abstract excerpt

<title>Abstract</title> <p>In clinical settings, patients with SNTA1 point mutations are often associated with rare arrhythmias, including Long QT syndrome, Brugada syndrome, and sudden infant death syndrome. Previous studies on SNTA1 have predominantly utilized nonhuman cardiomyocyte models. This study aims to elucidate the phenotype of SNTA1 deficiency using human cardiomyocytes. Using CRISPR/Cas9 technology, w...

Topics

Open a Topic to create a Post that cites this publication.

• Calcium
• Cell Line
• Induced Pluripotent Stem Cells
• Long QT Syndrome
• Mutation
• Mutation, Missense
• Myocytes, Cardiac
• Phenotype

Identifiers and source

Literature Corpus work

734a9e4e-9291-5441-9b43-ab25e760b37b

DOI

10.21203/rs.3.rs-6120127/v1