Article

SNTA1-deficient human cardiomyocytes are associated with increased structural components, calcium handling disorder, and shorter field potential duration

2022-01-28

Abstract excerpt

<h4>Background: </h4> α-1-syntrophin (SNTA1), a protein encoded by SNTA1 , is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on nonhuman cardiomyocytes. Our study was designed to identify phenotype of SNTA1 -deficient using human cardiomyocytes. Methods SNTA1 was knocked out in H9 cell line using CRISPR-Cas...

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Literature Corpus work: db0fea03-e220-5a6a-b631-f079cb21d76b
DOI: 10.21203/rs.3.rs-1255102/v1

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