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Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes

1 May 2023

Abstract excerpt

Triadin knockout syndrome (TKOS) is a malignant arrhythmia disorder caused by recessive null variants in TRDN -encoded cardiac triadin. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) were generated from two unrelated TKOS patients and an unrelated control. CRISPR-Cas9 gene editing was used to insert homozygous TRDN-p.D18fs ∗ 13 into a control line to generate a TKOS model (TRDN −/− ). Western...

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PMID: 37163978
DOI: 10.1016/j.stemcr.2023.04.005

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