Article

hERG - Deficient Human Embryonic Stem Cell - Derived Cardiomyocytes for Modelling QT Prolongation

2021-02-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Long-QT syndrome type 2 (LQT2) is common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by <italic>human ether-a-go-go-related gene</italic> (hERG) deficiency is still unclear. In this study, we generated an hERG-deficient human cardiomyocyte (CM) model that simulates ‘human homozygous hERG m...

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Literature Corpus work: 2eeca534-03ee-5b29-abb5-d0229425c37a
DOI: 10.21203/rs.3.rs-225955/v1

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