Article

A Brugada-related KCNT1 mutation unveils its conductance-independent activation of store-operated Ca <sup>2+</sup> entry

2026-06-12

Abstract excerpt

<h4>Background</h4> Potassium sodium-activated channel subfamily T member 1 (KCNT1) is a Na + -activated K + channel, associated with epilepsy and cardiac diseases. Besides K + conductance, KCNT1 is also involved in Ca 2+ handling. KCNT1:R1106Q was identified in a Brugada Syndrome (BrS) patient; however, its pathological characteristics regarding either K + or Ca 2+ homeostasis remain to be fully elucidate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d5e2a9f-450c-55c5-aeaa-49a9a47101a5
DOI: 10.64898/2026.06.12.731813

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Brugada-related KCNT1 mutation unveils its conductance-independent activation of store-operated Ca <sup>2+</sup> entryDOI 10.64898/2026.06.12.731813Read

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and DiseaseSemantic proximity Read

Disrupted CaV1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C-E1115K iPS cell model.Semantic proximity Read

TRPC1.Semantic proximity Read

The Functional Properties, Physiological Roles, Channelopathy and Pharmacological Characteristics of the Slack (KCNT1) Channel.Semantic proximity Read

KV Channel-Interacting Proteins in Neurological and Cardiovascular System: An Updated ReviewSemantic proximity Read

SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocitySemantic proximity Read

Characterization of the CACNA1C-R518C Missense Mutation in the Pathobiology of Long-QT Syndrome Using Human Induced Pluripotent Stem Cell Cardiomyocytes Shows Action Potential Prolongation and L-Type Calcium Channel PerturbationSemantic proximity Read

Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient.Semantic proximity Read

KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongationSemantic proximity Read

Gene Therapy with the N-terminal Fragment of Na <sub>v</sub> 1.5 for Cardiac Channelopathies: A Novel Transcomplementation Mechanism Potentiating the Cardiac Sodium CurrentSemantic proximity Read

Hydrogen-Induced Calcium Influx via the TRPC4-TRPC4AP AxisSemantic proximity Read

TRPC4- and TRPC4-containing channels.Semantic proximity Read