Article

KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation

2022-01-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>The slowly activated delayed-rectifier potassium current (I<sub>Ks</sub>) composed of KCNQ1 is one of the main currents in the process of repolarization. KCNQ1 mutation can lead to the occurrence of long-QT syndrome type 1 (LQT1). I<sub>Ks</sub> does not participate in repolarization in mice; thus, no good model for the mechanism research and drug screening of LQT...

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Literature Corpus work: d96fda2d-acb1-5703-89b3-5c6fdd8f52a0
DOI: 10.21203/rs.3.rs-1250091/v1

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