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Article

SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder.

Stem cell research & therapy - 30 Jun 2022

Dong Tao, Zhao Yan, Jin Hai-Feng, Shen Lei, Lin Yan, Si Long-Long, Chen Li, Liu Ji-Cheng

Abstract excerpt

BACKGROUND: α-1-syntrophin (SNTA1), a protein encoded by SNTA1, is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on non-human cardiomyocytes. This study was designed to identify the phenotype of SNTA1-deficiency using human cardiomyocytes. METHODS: SNTA1 was knocked out in the H9 embryonic stem cell line...

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Identifiers

PMID: 35773684
DOI: 10.1186/s13287-022-02955-4
PMCID: PMC9248201

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