Article

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

2024-09-24

Abstract excerpt

<h4>Background</h4> The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD). Positron emission tomography (PET) studies of mGluR5 using [ 18 F]FPEB indicate a reduction of receptor binding that is focused in the medial temporal lobe in AD. Synaptic loss due to AD measured through syn...

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Literature Corpus work: 7345dc63-a808-5af1-92f2-76ea265110fe
DOI: 10.1101/2024.09.21.614277

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