Article

Synaptic density deficits in patients with a psychotic disorder and unaffected siblings

2025-06-06

Abstract excerpt

<h4>Background</h4> Schizophrenia spectrum disorders (SSD) are associated with cognitive dysfunction, which has been linked to excessive synaptic pruning. To disentangle SSDs genetic vulnerability from secondary effects, we investigated synaptic density in individuals with SSD, unaffected siblings of individuals with SSD, and healthy controls (HC). <h4>Methods</h4> We recruited 24 SSD individuals, 25 unaffected si...

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Literature Corpus work: 229d9393-cfa2-5ea5-b7d0-c49853083807
DOI: 10.1101/2025.06.05.25328865

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