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Article

Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

Annals of clinical and translational neurology - 1 Jul 2021

Malpetti Maura, Holland Negin, Jones P Simon, Ye Rong, Cope Thomas E, Fryer Tim D, Hong Young T, Savulich George, Rittman Timothy, Passamonti Luca, Mak Elijah, Aigbirhio Franklin I, O'Brien John T, Rowe James B

Abstract excerpt

Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [11 C]UCB-J PET to quantify synaptic density in comparison with 19 healthy controls and one symptomatic patient with behavioural variant frontotemporal dementia. The three pre-symptomatic C9orf72 carriers showed reduced synaptic...

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Identifiers

PMID: 34133849
DOI: 10.1002/acn3.51407
PMCID: PMC8283163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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