Article

Synaptic loss in behavioural variant frontotemporal dementia revealed by [<sup>11</sup>C]UCB-J PET

2022-02-01

Abstract excerpt

Synaptic loss is an early feature of neurodegenerative disease models, and is often severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) imaging with radiotracers that bind to synaptic vesicle glycoprotein 2A enables quantification of synapses in vivo . This study used [ 11 C]UCB-J PET in people with behavioural variant frontotemporal dementia (bvFTD), testi...

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Literature Corpus work: 031a0822-a11b-5937-b6f5-45024f439484
DOI: 10.1101/2022.01.30.22270123

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