Article

Delta-catenin is required for cell proliferation in virus positive Merkel cell carcinoma cell lines but not in human fibroblasts

2025-03-14

Abstract excerpt

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer often driven by the integration of Merkel cell polyomavirus (MCPyV) into the host genome and the persistent expression of its viral oncoproteins, small tumor (ST) antigen and truncated large tumor (t-LT) antigen. While human fibroblasts support MCPyV replication, the cell of origin for MCC remains unknown. We hypothesized that MCPyV init...

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Literature Corpus work: 73268532-5574-5df5-a42b-d45e058570b2
DOI: 10.1101/2025.03.12.642815

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Delta-catenin is required for cell proliferation in virus positive Merkel cell carcinoma cell lines but not in human fibroblastsDOI 10.1101/2025.03.12.642815Read

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