Article
Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma.
Genome medicine - 18 Mar 2020
Starrett Gabriel J, Thakuria Manisha, Chen Tianqi, Marcelus Christina, Cheng Jingwei, Nomburg Jason, Thorner Aaron R, Slevin Michael K, Powers Winslow, Burns Robert T, Perry Caitlin, Piris Adriano, Kuo Frank C, Rabinowits Guilherme, Giobbie-Hurder Anita, MacConaill Laura E, DeCaprio James A
Abstract excerpt
BACKGROUND: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin caused by either the integration of Merkel cell polyomavirus (MCPyV) and expression of viral T antigens or by ultraviolet-induced damage to the tumor genome from excessive sunlight exposure. An increasing number of deep sequencing studies of MCC have identified significant differences between the number and types...
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