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Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential

30 Aug 2023

Abstract excerpt

Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective targeted treatments. A better understanding of the MCPyV life cycle and its oncogenic mechanisms is needed to unveil novel strategies for the prevention and treatment...

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PMID: 37647312
DOI: 10.1371/journal.ppat.1011598

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