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Article

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

17 Jan 2008

Abstract excerpt

Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin. We studied MCC samples by digital transcriptome subtraction and detected a fusion transcript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase. Further investigation led to identification and...

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Identifiers

PMID: 18202256
DOI: 10.1126/science.1152586

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