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Article

LT and SOX9 expression are associated with gene sets that distinguish Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative Merkel cell carcinoma.

The British journal of dermatology - 17 May 2024

Torre-Castro Juan, Rodríguez Marta, Alonso-Alonso Ruth, Mendoza Cembranos María Dolores, Díaz-Alejo Jesús Frutos, Rebollo-González Marcos, Borregón Jennifer, Nájera Botello Laura, Mahillo-Fernández Ignacio, Samimi Mathab, Kervarrec Thibault, Requena Luis, Piris Miguel Ángel

Abstract excerpt

BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive malignant neuroendocrine tumour. There are two subsets of MCC, one related to Merkel cell polyomavirus (MCPyV) and the other to ultraviolet radiation (UVR). MCPyV-positive and MCPyV-negative MCCs have been considered to be different tumours, as the former harbour few DNA mutations and are not related to UVR, and the latter usually arise in sun-exposed areas...

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Share to Antigens, Viral, Tumor
Share to Carcinoma, Merkel Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

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Share to Skin Neoplasms

Share to SOX9 Transcription Factor

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Identifiers

PMID: 38261397
DOI: 10.1093/bjd/ljae033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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