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Merkel Cell Polyomavirus: Molecular Insights into the Most Recently Discovered Human Tumour Virus

27 Jun 2014

Abstract excerpt

A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally integrated into the majority of MCC tumours, which require MCPyV oncoproteins to survive. Since its discovery,...

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PMID: 24978434
DOI: 10.3390/cancers6031267

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