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Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC

7 Oct 2022

Abstract excerpt

Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these MCPyV+ MCC tumors, clonal integration of the viral genome results in the continued expression of two viral proteins: the viral small T antigen (ST) and a...

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PMID: 36298759
DOI: 10.3390/v14102204

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