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Merkel Cell Polyomavirus: Oncogenesis in a Stable Genome

30 Dec 2021

Abstract excerpt

Merkel cell polyomavirus (MCV) is the causative agent for the majority of Merkel cell carcinoma (MCC) cases. Polyomavirus-associated MCC (MCCP) is characterized by the integration of MCV DNA into the tumor genome and a low tumor mutational burden. In contrast, nonviral MCC (MCCN) is characterized by a high tumor mutational burden induced by UV damage. Since the discovery of MCV, much work in the field has focused...

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PMID: 35062263
DOI: 10.3390/v14010058

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