Article

REPEATED INJURY PROMOTES TRACHEOBRONCHIAL TISSUE STEM CELL ATTRITION

2021-01-09

Abstract excerpt

<h4>SUMMARY</h4> Chronic lung disease has been attributed to stem cell aging and/or exhaustion. To address this issue, we investigated the lifespan of tracheobronchial tissue stem cells (TSC) over time and in response to repeated injury. Chromatin and nucleotide labeling studies in mice indicated that: 1) injury activated a subset of the TSC pool and that this process conserved TSC over time; and 2) activated TSC...

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Literature Corpus work: 73201d02-3b59-58d4-874a-850eb5c5810b
DOI: 10.1101/2021.01.08.425956

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