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Article

UHRF1 is required for basal stem cell proliferation in response to airway injury

13 Jun 2017

Abstract excerpt

Abstract Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway basal cells, we discovered that the epigenetic regulator ubiquitin-like with PHD and ring finger domain-containing protein 1 (UHRF1) is critical for regulating...

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PMID: 28626588
DOI: 10.1038/celldisc.2017.19

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