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Article

Repeated Injury Promotes Tracheobronchial Tissue Stem Cell Attrition

21 Sept 2021

Abstract excerpt

Chronic lung disease has been attributed to stem cell aging and/or exhaustion. We investigated these mechanisms using mouse and human tracheobronchial tissue-specific stem cells (TSC). In mouse, chromatin labeling and flow cytometry demonstrated that naphthalene (NA) injury activated a subset of TSC. These activated TSC continued to proliferate after the epithelium was repaired and a clone study demonstrated that...

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PMID: 34546001
DOI: 10.1002/sctm.21-0032

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