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Distal lung epithelial progenitor cell function declines with age

26 Jun 2020

Abstract excerpt

Tissue stem cell exhaustion is a key hallmark of aging, and in this study, we characterised its manifestation in the distal lung. We compared the lungs of 3- and 22-month old mice. We examined the gross morphological changes in these lungs, the density and function of epithelial progenitor populations and the epithelial gene expression profile. Bronchioles became smaller in their cross-sectional area and...

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PMID: 32591591
DOI: 10.1038/s41598-020-66966-y

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