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Article

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis

7 Sept 2016

Abstract excerpt

Telomeres are short in type II alveolar epithelial cells (AECs) of patients with idiopathic pulmonary fibrosis (IPF). Whether dysfunctional telomeres contribute directly to development of lung fibrosis remains unknown. The objective of this study was to investigate whether telomere dysfunction in type II AECs, mediated by deletion of the telomere shelterin protein TRF1, leads to pulmonary fibrosis in mice (...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Occupational and environmental lung diseases
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Identifiers

PMID: 27699234
DOI: 10.1172/jci.insight.86704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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