Article

Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma

2025-02-08

Abstract excerpt

<h4>Purpose</h4> We previously identified an oncogenic role for the transcription factor HNF1A in pancreatic ductal adenocarcinoma (PDAC). However, the role of HNF1A in the metastatic progression of PDAC remains unknown and targeting modalities for HNF1A -dependent phenotypes have yet to be identified. <h4>Experimental Design</h4> Transwell chambers were used to assess the effects of HNF1A and FGFR4 modulation o...

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Literature Corpus work: 7317c2f2-625d-52d2-998f-b7dd46b2bfcc
DOI: 10.1101/2025.02.06.636643

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