Article

Metastatic site influences driver gene function in pancreatic cancer

2024-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Driver gene mutations can increase the metastatic potential of the primary tumor 1–3 , but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is inactivation of SMAD4 – a transcriptional effector of TGFβ signaling – which is a hallmark of multiple gastrointestinal malignancies 4,5 . SMAD4 inactivation mediates TGFβ’s remarkable anti-t...

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Literature Corpus work: 30233528-68ca-5dd2-bb59-8d977460387e
DOI: 10.1101/2024.03.17.585402

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