Loss of FGFR4 promotes the malignant phenotype of PDAC.

doi:10.1038/s41388-022-02432-5

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Article

Loss of FGFR4 promotes the malignant phenotype of PDAC.

Oncogene - 1 Sept 2022

D'Agosto Sabrina, Pezzini Francesco, Veghini Lisa, Delfino Pietro, Fiorini Claudia, Temgue Tane Gael D, Del Curatolo Anais, Vicentini Caterina, Ferrari Giorgia, Pasini Davide, Andreani Silvia, Lupo Francesca, Fiorini Elena, Lorenzon Giulia, Lawlor Rita T, Rusev Borislav, Malinova Antonia, Luchini Claudio, Milella Michele, Sereni Elisabetta, Pea Antonio, Bassi Claudio, Bailey Peter, Scarpa Aldo, Bria Emilio, Corbo Vincenzo

Abstract excerpt

Transcriptomic analyses of pancreatic ductal adenocarcinoma (PDAC) have identified two major epithelial subtypes with distinct biology and clinical behaviours. Here, we aimed to clarify the role of FGFR1 and FGFR4 in the definition of aggressive PDAC phenotypes. We found that the expression of FGFR4 is exclusively detected in epithelial cells, significantly elevated in the classical PDAC subtype, and associates...

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PMID: 35963908
DOI: 10.1038/s41388-022-02432-5
PMCID: PMC9481460

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