Article

Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma

2025-04-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Although transcriptomic studies have stratified pancreatic ductal adenocarcinoma (PDAC) into clinically relevant subtypes, classical or basal-like, further research is needed to identify the transcriptional regulators of each subtype. Previous studies identified HNF4α as a key regulator of the classical subtype, but the distinct contributions of its isoforms (P1 and P2), whi...

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Literature Corpus work: 466a7095-7431-524e-91ca-a55b9c80b2d3
DOI: 10.1101/2025.03.31.646428

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