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Mena (ENAH) Promotes KRAS-Driven Tumor Growth and Metastatic Progression in Pancreatic Ductal Adenocarcinoma

2026-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic pancreatic ductal adenocarcinoma (PDAC) remains incurable and is projected to become the second leading cause of cancer-related death by 2030. Despite therapeutic advances, median survival remains under one year. Activating KRAS mutations drive the majority of PDAC and underlie their highly aggressive behavior. Although emerging KRAS inhibitors show promise, resistance limits their cl...

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Literature Corpus work
747c38ef-72b6-54a3-a829-aab28add1d3d
DOI
10.64898/2026.01.07.698161
Open publication

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