Article

Genome-scale activation screen reveals lncRNA HNF1A-AS1 as a novel therapeutic target for pancreatic cancer metastasis

2024-12-24

Abstract excerpt

<title>Abstract</title> <p>Background Long non-coding RNAs (LncRNAs) have emerged as pivotal biomarkers and regulators across various cancers. In pancreatic cancer (PC), however, the mechanisms underlying the expression and functional roles of lncRNAs remain inadequately elucidated. Methods CRISPR/CRISPR-associated protein 9 (Cas9) single-guide RNA (sgRNA)-pooled lncRNA libraries were used to screen for the cri...

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Literature Corpus work: e81b9bcc-e913-500a-b059-f4a2b6276c4f
DOI: 10.21203/rs.3.rs-5388928/v1

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