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Article

Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Dec 2008

Zucchini Silvia, Buzzi Andrea, Barbieri Mario, Rodi Donata, Paradiso Beatrice, Binaschi Anna, Coffin J Douglas, Marzola Andrea, Cifelli Pierangelo, Belluzzi Ottorino, Simonato Michele

Abstract excerpt

Fibroblast growth factor 2 (FGF-2) has multiple, pleiotropic effects on the nervous system that include neurogenesis, neuroprotection and neuroplasticity. Thus, alteration in FGF-2 expression patterns may have a profound impact in brain function, both in normal physiology and in pathology. Here, we used FGF-2 transgenic mice (TgFGF2) to study the effects of endogenous FGF-2 overexpression on susceptibility to...

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Identifiers

PMID: 19052202
DOI: 10.1523/JNEUROSCI.1472-08.2008
PMCID: PMC3844742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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