Article
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
The Journal of clinical investigation - 1 Feb 2014
Winkelmann Aline, Maggio Nicola, Eller Joanna, Caliskan Gürsel, Semtner Marcus, Häussler Ute, Jüttner René, Dugladze Tamar, Smolinsky Birthe, Kowalczyk Sarah, Chronowska Ewa, Schwarz Günter, Rathjen Fritz G, Rechavi Gideon, Haas Carola A, Kulik Akos, Gloveli Tengis, Heinemann Uwe, Meier Jochen C
Abstract excerpt
The mechanisms that regulate the strength of synaptic transmission and intrinsic neuronal excitability are well characterized; however, the mechanisms that promote disease-causing neural network dysfunction are poorly defined. We generated mice with targeted neuron type-specific expression of a gain-of-function variant of the neurotransmitter receptor for glycine (GlyR) that is found in hippocampectomies from...
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