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Article

PTEN deletion increases hippocampal granule cell excitability in male and female mice

30 Aug 2017

Abstract excerpt

Deletion of the mTOR pathway inhibitor PTEN from postnatally-generated hippocampal dentate granule cells causes epilepsy. Here, we conducted field potential, whole cell recording and single cell morphology studies to begin to elucidate the mechanisms by which granule cell-specific PTEN-loss produces disease. Cells from both male and female mice were recorded to identify sex-specific effects. PTEN knockout granule...

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PMID: 28855130
DOI: 10.1016/j.nbd.2017.08.014

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