Article

Enhanced cell viscosity: a new phenotype associated with lamin A/C alterations

2022-07-19

Abstract excerpt

Lamin A/C is a well-established key contributor to nuclear stiffness and its role in nucleus mechanical properties has been extensively studied. However, its impact on whole cell mechanics has been poorly addressed, even less so in terms of measurable physical parameters. In the present study, microfluidic experiments combined with theoretical analyses were performed to provide a quantitative estimation of the who...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69bc42da-19a8-5116-a3fe-0c58eb8a5c01
DOI: 10.1101/2022.07.18.500411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhanced cell viscosity: a new phenotype associated with lamin A/C alterationsDOI 10.1101/2022.07.18.500411Read

High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cellsSemantic proximity Read

Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathiesSemantic proximity Read

Dissecting the contribution of actin and vimentin intermediate filaments to mechanical phenotype of suspended cells using high-throughput deformability measurements and computational modeling.Semantic proximity Read

Real-time viscoelastic deformability cytometry: High-throughput mechanical phenotyping of liquid and solid biopsies.Semantic proximity Read

High-throughput single-cell mechanical phenotyping with real-time deformability cytometry.Semantic proximity Read

Lamin A/C Mechanotransduction in Laminopathies.Semantic proximity Read

Persistent confined migration confers permanent nuclear and functional changes in migrating cellsSemantic proximity Read

Quantitative Analysis of Cytoplasmic Viscosity in Colorectal Cancer Cells by Differential Dynamic Microscopy of Genetically Encoded NanoparticlesSemantic proximity Read

Non-contact microfluidic analysis of the stiffness of single large extracellular vesicles from IDH1-mutated glioblastoma cellsSemantic proximity Read

Multiple particle tracking analysis in isolated nuclei reveals the mechanical phenotype of leukemia cells.Semantic proximity Read

High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications.Semantic proximity Read

Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithiumSemantic proximity Read