Article
From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy.
Cell communication and signaling : CCS - 27 Mar 2024
Veltrop R J A, Kukk M M, Topouzidou K, Didden L, Muchir A, van Steenbeek F G, Schurgers L J, Harakalova M
Abstract excerpt
Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge. Currently, there is no effective treatment for lamin-related diseases. Exploring the intricate molecular landscape underlying this condition, with a specific focus on abnormal mechanotransduction, will propel our understanding of...
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