Article
Single molecule analysis of lamin dynamics.
Methods (San Diego, Calif.) - 15 Mar 2019
Serebryannyy Leonid A, Ball David A, Karpova Tatiana S, Misteli Tom
Abstract excerpt
The nuclear envelope (NE) is an essential cellular structure that contributes to nuclear stability, organization, and function. Mutations in NE-associated proteins result in a myriad of pathologies with widely diverse clinical manifestations, ages of onsets, and affected tissues. Notably, several hundred disease-causing mutations have been mapped to the LMNA gene, which encodes the intermediate filament proteins...
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