Article

Single molecule analysis of lamin dynamics

2018-07-17

Abstract excerpt

The nuclear envelope (NE) is an essential cellular structure that contributes to nuclear stability, organization, and function. Mutations in NE-associated proteins result in a myriad of pathologies with widely diverse clinical manifestations, ages of onsets, and affected tissues. Notably, several hundred disease-causing mutations have been mapped to the LMNA gene, which encodes the intermediate filament proteins...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d087cff-05b4-5269-bcec-21feae2053a7
DOI: 10.1101/371104

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single molecule analysis of lamin dynamicsDOI 10.1101/371104Read

Single molecule analysis of lamin dynamics.Semantic proximity Read

How nuclear envelope dynamics can direct laminopathy phenotypes.Semantic proximity Read

Cardiomyopathic mutations of lamin A perturb mutual interactions of lamin, nuclear membrane, and chromatin leading to LLPSSemantic proximity Read

Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathiesSemantic proximity Read

When lamins go bad: nuclear structure and disease.Semantic proximity Read

Dynamics and Structure-Function Relationships of the Lamin B Receptor (LBR).Semantic proximity Read

Microdynamics of lamin A Ig-fold domain regulates higher order assembly of the proteinSemantic proximity Read

Structural and Mechanical Aberrations of the Nuclear Lamina in Disease.Semantic proximity Read

The luminal AAA+ ATPase torsinA mediates distinct mechanisms of nuclear-cytoplasmic communication by adopting different functional assembly statesSemantic proximity Read

Correlating Protein Aggregate Structure with Cellular Function in Differentiated Muscle Cells: Discriminating Pathogenic from Non-Pathogenic FormsSemantic proximity Read

Single-molecule imaging and tracking on clinical liquid biopsies reveals cancer biomarkers nanoscale organization and heterogeneitySemantic proximity Read

Inter-lamin interactions control meshwork topology in a polymer-gel model of nuclear laminaSemantic proximity Read