Article
Viscoelastic behavior of cardiomyocytes carrying LMNA mutations.
Biorheology - 1 Jan 2020
Borin Daniele, Peña Brisa, Taylor Matthew R G, Mestroni Luisa, Lapasin Romano, Sbaizero Orfeo
Abstract excerpt
BACKGROUND: Laminopathies are genetic diseases caused by mutations in the nuclear lamina. OBJECTIVE: Given the clinical impact of laminopathies, understanding mechanical properties of cells bearing lamin mutations will lead to advancement in the treatment of heart failure. METHODS: Atomic force microscopy (AFM) was used to analyze the viscoelastic behavior of neonatal rat ventricular myocyte cells expressing...
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