Changes in Chromatin Organisation and Mechanotransduction Mediated by Mutant Lamins in Laminopathies.

Abstract excerpt

The filamentous nuclear lamina network is predominantly made up of lamin proteins, which play pivotal roles in maintaining nuclear architecture, chromatin structure, mechanotransduction and various other nuclear processes. Among the lamin proteins, A type is the principal mechanical component of the nucleus and controls gene expression via direct interactions with chromatin and chromatin modulator proteins....

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