Article
Structural and Mechanical Aberrations of the Nuclear Lamina in Disease.
Cells - 11 Aug 2020
Stiekema Merel, van Zandvoort Marc A M J, Ramaekers Frans C S, Broers Jos L V
Abstract excerpt
The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell. Mutations in the genes encoding for lamins lead to the rare diseases termed laminopathies. However, not only laminopathies show alterations in the nuclear lamina. Deregulation of lamin...
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