Article

PTEN Regulates Myofibroblast Activation in Valvular Interstitial Cells based on Subcellular Localization

2024-07-02

Abstract excerpt

Aortic valve stenosis (AVS) is characterized by altered mechanics of the valve leaflets, which disrupts blood flow through the aorta and can cause left ventricle hypotrophy. These changes in the valve tissue result in activation of resident valvular interstitial cells (VICs) into myofibroblasts, which have increased levels of αSMA in their stress fibers. The persistence of VIC myofibroblast activation is a hallmar...

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Literature Corpus work: 728ab031-1884-53b4-a653-7dddb9bfd00f
DOI: 10.1101/2024.06.30.601424

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