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Article

Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and Disease

17 Aug 2015

Abstract excerpt

The heart valve interstitial cell (VIC) population is dynamic and thought to mediate lay down and maintenance of the tri-laminar extracellular matrix (ECM) structure within the developing and mature valve throughout life. Disturbances in the contribution and distribution of valve ECM components are detrimental to biomechanical function and associated with disease. This pathological process is associated with...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 26527432
DOI: 10.3390/jcdd2030214

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