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Article

TGF-beta1 pathway activation and adherens junction molecular pattern in nonsyndromic mitral valve prolapse.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Rizzo Stefania, Basso Cristina, Lazzarini Elisabetta, Celeghin Rudy, Paolin Adolfo, Gerosa Gino, Valente Marialuisa, Thiene Gaetano, Pilichou Kalliopi

Abstract excerpt

AIMS: Dysregulation of the transforming growth factor beta (TGF-β) 1 pathway has been associated with either syndromic or isolated mitral valve (MV) prolapse due to myxoid degeneration (floppy MV). The activation of Smad receptor-mediated intracellular TGF-β pathway and its effect on adherens junction (AJ) molecular pattern of activated valvular interstitial cells (VICs) in MV prolapse are herein investigated....

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PMID: 26345253
DOI: 10.1016/j.carpath.2015.07.009

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TIMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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