Article

TRPV4-mediated Mechanotransduction Regulates the Differentiation of Valvular Interstitial Cells to Myofibroblasts: Implications for Aortic Stenosis

2024-11-06

Abstract excerpt

<h4>ABSTRACT</h4> As aortic valve stenosis (AVS) progresses, the valve tissue also stiffens. This increase in tissue stiffness causes the valvular interstitial cells (VICs) to transform into myofibroblasts in response. VIC-to-myofibroblast differentiation is critically involved in the development of AVS. Herein, we investigated the role of mechanosensitive Ca 2+ -permeant transient receptor potential vanilloid 4...

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Literature Corpus work: 253b5fb1-59f7-56b7-a329-97f4ca77c02f
DOI: 10.1101/2024.11.05.622116

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