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Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular smooth muscle cells

30 Oct 2023

Abstract excerpt

Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease and a key risk factor for cardiovascular disease events. The increased stiffness of arteries triggers a phenotypic switch, hypermigration, and hyperproliferation of vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia and accelerated neointima formation. However, the mechanism underlying this...

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PMID: 37915752
DOI: 10.1063/5.0150532

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