Article

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8 <sup>+</sup> T cells

2022-01-27

Abstract excerpt

<h4>Summary/Abstract</h4> We previously identified the adhesion molecule PSGL-1 as a T cell intrinsic immune checkpoint regulator of T cell exhaustion. Here we show that the ability of PSGL-1 to restrain TCR sginaling correlates with decreased expression of the Zap70 inhibitor Ubash3b (Sts-1) in PSGL-1-deficient T cells. PSGL-1-deficency in T cells supports antitumor responses to a PD-1 blockade resistant melano...

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Identifiers and source

Literature Corpus work: 721b1ed4-02be-5be3-84ef-264372e7f197
DOI: 10.1101/2022.01.24.477602

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